23andMe Holding Co. (NASDAQ: ME) shares ducked Tuesday, as the a leading human genetics and biopharmaceutical company announced that it will display three poster presentations on 23ME-00610, a first-in-class anti-CD200R1 antibody, and two on 23ME-01473, an anti-ULBP6 monoclonal antibody, at the European Society for Medical Oncology (ESMO) Congress 2024, taking place September 13 – September 17 in Barcelona.
23andMe will present additional preliminary clinical data, including efficacy data, for the clear-cell renal-cell carcinoma and high tumor microsatellite instability and/or high tumor mutational burden patient cohorts in the Phase 2a portion of its ongoing Phase 1/2a clinical trial evaluating 23ME-00610, as well as share further analyses on an exploratory tissue-based biomarker, CD200.
In Phase 2 data presented at the American Society of Clinical Oncology (ASCO) in June, monotherapy 23ME-00610 demonstrated a continued acceptable safety and tolerability profile and preliminary evidence of clinical benefit in neuroendocrine and ovarian cohorts, including one confirmed partial response in a patient with well-differentiated pancreatic neuroendocrine cancer. Additionally, data showed early evidence pointing to CD200 as a potential tissue-based biomarker.
The Company will present preclinical data on the 23ME-01473 program, as well as a trials in progress presentation on the Phase 1 clinical trial that began in March 2024. 23ME-01473 targets soluble ULBP6, which is released by cancer cells to promote an immunosuppressive tumor microenvironment.
ME shares let go of 0.6 cents, or 1.8%, to 31 cents.
